Systemic mastocytosis – a diagnostic challenge

Systemic mastocytosis – a diagnostic challenge

Mastocytosis refers to a group of disorders characterized by the infiltration of clonally derived mast cells to the skin or extracutaneous tissues resulting in a heterogeneous clinical picture. It is a rare hematologic disorder in all its forms. The exact incidence is unknown; it affects patients of any age and males and females equally. Its molecular pathogenesis is incompletely understood. Th...

Systemic mastocytosis involving bone : a diagnostic challenge for the radiologist

Pseudoachalasia: a diagnostic challenge

Here, we present a case of a 78-year-old man that underwent gastrointestinal endoscopy because of one- monthhistory of dysphagia to liquids and solid foods with accompanying weight loss. On endoscopy, there was distalesophageal stenosis. Multiple biopsies were obtained. Histologic examination of the samples revealed normaltissue. The stenosis was treated by dilatation and abdomino pelvic comput...

Unruptured Middle Cerebral Artery Aneurysm in a Patient with Systemic Lupus Erthematosus: A Diagnostic Challenge

A 22-year-old female patient presented to the Emergency Department of a tertiary care hospital with symptoms of headache and nausea. She has been on a regular follow-up for the preceding three and a half years after being diagnosed as systemic lupus erythematosus (SLE). She had been treated earlier for SLE nephritis in the same institution, and had two relapses of nephrotic syndrome in the last...

Laryngeal Paraganglioma: A Diagnostic Challenge

Paragangliomas are neoplasms of neural crest origin. In the head and neck, they uncommonly involve the larynx. The distinction between paragangliomas and other neuroendocrine tumors can be difficult. Precise diagnosis is important in order to optimize patient treatment. Diagnosis relies mostly on histopathologic examination followed by immunohistochemistry. Here we report a 77-year-old woman wi...